Your cart

Role of Transforming Growth Factor Beta-1

TGF-Beta 1 appears to inhibit the rate of hair follicle lengthening in vitro and in vivo in mice to promote the regression phase of the organ culture of human hair follicles. Thus, TGF-Beta 1 is considered as a catagen induction...

Hair Follicle Microinflammation

The limited success rate of treatment of AGA with hair growth promoters or modulators of androgen metabolism means that further pathogenic pathways may be taken into account. The implication of microscopic follicular inflammation in the pathogenesis of AGA has recently...

Androgen Metabolism and the Androgen Receptor

Scientific Review by Dr. Luna, MDMedical Director, Roots Hair Club Androgen metabolism comprises glandular and extraglandular production, transport, target cell metabolism, and cellular response. The androgen metabolism pathway begins with pregnenolone, a 21 carbon steroid substrate, converted from cholesterol. Testosterone...

Expression of Insulin-Like Growth Factors

Of all the cytokines or growth factors that have been postulated to play a role in hair follicle, insulin-like growth factor- 1 (IGF-1) is known to be regulated by androgens. Dermal Papila cells from balding scalp follicles were found to...

Hair Follicle Cycling and Signaling Molecules

Medical Review by Dr. Luna, MDMedical Director, Roots Hair Club Hair growth is believed to be regulated by the interactive signals between the epithelial parts and mesenchymal-derived DP cells. Several cytokines, growth factors, hormones, neuropeptides and enzymes are involved in...