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Dandruff Causes Hair Loss


The lipophilic yeast Malassezia spp. normally inhabits the scalp, making up about 45% of its resident microflora. In patients with dandruff, it is the predominant yeast type with about 75%. Modern classification and nomenclature of Malassezia spp. are based on DNA typing. The most common types found on the scalp are M. restricta and M. globosa, the latter of which in particular has a major role in the development of dandruff given its high level of lipase activity resulting in breakdown of sebum to free fatty acids that auto-oxidize to skin-irritating lipoperoxides.

Therefore, the mainstay for treatment of dandruff and preserving a healthy scalp is the use of anti-microbial shampoos that are effective in inhibiting Malassezia yeasts. Appropriate shampoo formulation allowing efficacy with short contact time.

 

Pyo HK, Yoo HG, Won CH, et al. The effect of tripeptide-copper complex on human hair growth in vitro. Archives of pharmacal research. 2007;30:834-839.

Yano K, Brown LF, Detmar M. Control of hair growth and follicle size by VEGF-mediated angiogenesis. The Journal of clinical investigation. 2001;107:409-417.

Shin H, Cho A, Kim DY, et al. Enhancement of Human Hair Growth Using Ecklonia cava Polyphenols. Annals of Dermatology. 2016;28:15-21.

Park B, Kim W, Choi J, et al. Hair growth stimulated by conditioned medium of adipose-derived stem cells is enhanced by hypoxia: evidence of increased growth factor secretion. Biomedical Research. 2010;31:27-34

Weger N, Schlake T. IGF-I Signalling Controls the Hair Growth Cycle and the Differentiation of Hair Shafts. Journal of Investigative Dermatology. 2005;125:873-882.

Schlake T. FGF signals specifically regulate the structure of hair shaft medulla via IGF-binding protein 5. Development. 2005;132:2981-2990.

Moore GP, Du Cros DL, Isaacs K, Pisansarakit P, Wynn PC. Hair growth induction: roles of growth factors. Annals of the New York Academy of Sciences. 1991;642:308.

Yoon S, Yoon J, Jo SJ, et al. A role of placental growth factor in hair growth. Journal of dermatological science. 2014;74:125.

Rezghi M, Fahimi S, Zakerin S. The Most Frequent Herbs Proposed by Iranian Traditional Medicine for Alopecia Areata. Iranian journal of medical sciences. 2016;41:S69

Rossi A, Iorio A, Di Nunno D, et al. Conditions simulating androgenetic alopecia. Journal of the European Academy of Dermatology and Venereology. 2015;29:1258-1264.

Tellez-Segura R. Involvement of Mechanical Stress in Androgenetic Alopecia. International journal of trichology. 2015;7:95.

Kelly Y, Blanco A, Tosti A. Androgenetic Alopecia: An Update of Treatment Options. Drugs. 2016;76:1349-1364

Arias-Santiago S, Camacho-Martínez F. Efectos adversos de los inhibidores de la 5-alfa-reductasa en la alopecia androgenética masculina ¿hay por qué preocuparse?. Actas Dermosifiliogr. 2016;107:709---711

Wessagowit V, Tangjaturonrusamee C, Kootiratrakarn T, et al. Treatment of male androgenetic alopecia with topical products containing Serenoa repens extract. Australasian Journal of Dermatology. 2016;57:e76-e82