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Role of Transforming Growth Factor Beta-1


TGF-Beta 1 appears to inhibit the rate of hair follicle lengthening in vitro and in vivo in mice to promote the regression phase of the organ culture of human hair follicles. Thus, TGF-Beta 1 is considered as a catagen induction marker in hair follicle. TGF-Beta 1 was shown to induce a rapid fibrotic response in vivo.

Moreover, chronic expression of TGF- Beta1 in adult dermal fibroblasts caused severe alopecia characterized by epidermal and follicular hyperproliferation, apoptosis, as well as dermal fibrosis and inflammation. Inui et al  demonstrated that androgen induced TGF- Beta 1 from the balding dermal papilla cells plays an important role in miniaturization of hair shaft. Also, a key function for TGF-Beta 1 in wound healing and fibrosis to regulate the expression of proteins of the fibrillar collagens and fibronectin.

TGF-Beta 1 is considered a potent anabolic factor that enhances connective tissue deposition and repair and which sustained signaling likely leads to the development of tissue fibrosis. Therefore, it can be inferred that the Testosterone-induced TGF- Beta 1 expression may induce perifollicular fibrosis the dermal fibroblasts, accelerate hair follicles into moving on catagen phase of hair cycle, and inhibits epithelial growth, which brings all together out miniaturization of hair follicles in AGA.

Tosti A, Piraccini BM, Iorizzo M, Voudouris S. The natural history of androgenetic alopecia. J Cosmet Dermatol 2005; 4: 41–43. 6 Rebora A. Alopecia areata incognita: a hypothesis. Dermatologica 1987; 174: 214–218.

Rebora A. Alopecia areata incognita. J Am Acad Dermatol 2011; 65: 1228.

Tosti A, Whiting D, Iorizzo M, Pazzaglia M, Vincenzi C, Micali G. The role of scalp dermoscopy in the diagnosis of alopecia areata incognita. J Am Acad Dermatol 2008; 59: 64–67.

Kossard S, Lee MS, Wilkinson B. Postmenopausal frontal fibrosing alopecia: a variant of lichen planopilaris. J Am Acad Dermatol 1997; 36: 59–66.

Kossard S, Shiell RC. Frontal fibrosing alopecia developing after hair transplantation for androgenetic alopecia. Int J Dermatol 2005; 44: 321–323.

Rossi A, Iorio A, Scali E et al. Frontal fibrosing alopecia and lichen planopilaris: clinical, dermoscopic and histological comparison. Eur J Inflamm 2013; 11: 311–314.

D’Ovidio R, Di Prima T. A possible continuum from reversible to irreversible forms of alopecia. Hair Ther Transplant 2013; 3: 1.

Betz RC, Lee YA, Bygum A et al. A gene for hypotrichosis simplex of the scalp maps to chromosome 6p21.3. Am J Hum Genet 2000; 66: 1979–1983. 14 Shimomura Y, Agalliu D, Vonica A et al. APCDD1 is a novel Wnt inhibitor mutated in hereditary hypotrichosis simplex. Nature 2010; 464: 1043–1047.

Blanpain C, Fuchs E. Epidermal stem cells of the skin. Annu Rev Cell Dev Biol 2006; 22: 339–373. 16 Price VH.

Androgenetic alopecia in adolescents. Pediatr Dermatol 2003; 71: 115–121. 17 Belgorosky A, Baquedano MS, Guercio G, Rivarola MA. Expression of the IGF and the aromatase/oestrogen receptor system in human adrenal tissues from early infancy to late puberty: implications for the development of adrenarche. Rev Endocr Metab Disord 2009; 10: 51–61.

Azzouni F, Godoy A, Li Y, Mohler J. The 5 Alpha-reductase isozyme family: a review of basic biology and their role in human diseases. Adv Urol 2012; 2012: 530121.

Saraco N, Berensztein E, Dardis A, Rivarola MA, Belgorosky A. Expression of the aromatase gene in the human prepubertal testis. J Pediatr Endocrinol Metab 2000; 13: 483–488.

Rossi A, Iorio A, Scali E et al. Aromatase inhibitors induce “male pattern hair loss” in women? Ann Oncol 2013; 24: 1710–1711.

Campo D, Pisani A. Psychogenic alopecia. G Ital Dermatol Venereol 2008; 143: 283–287. 22 Botchkarev VA. Stress and hair follicle exploring the connections. Am J Pathol 2003; 162: 709–712.

Steinert H. Uber das klinische und anatomische bild des muskelschwunds der myotoniker. Dtsch Z Nervenheilkd 1909; 37: 58.

Batten FE, Gibb HP. Myotonia atrophica. Brain 1909; 32: 187. 25 McKusick VA. Mendelian Inheritance in Man. Johns Hopkins University Press, Baltimore, 1984: 336.

Amorosi B, Giustini S, Rossi A, Giacanelli M, Calvieri S. Myotonic dystrophy (Steinert disease): a morphologic and biochemical hair study. Int J Dermatol 1999; 38: 434–438.

Kligman AM. Pathologic dynamics of human hair loss: telogen effluvium. Arch Dermatol 1961; 83: 175–198. 28 Rebora A. Telogen effluvium. Dermatology 1999; 195: 209–212. 29 Kligman AM. Acute telogen effluvium. Arch Dermatol 1961; 83: 175