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Procyanadin B2


Procyanidin B-2

Procyanidin B-2 is a polyphenol compound identified in apples which acts as a hair-growing factor. A kind of (proanthocyanidins and condensed tannins), one of the types of polyphenols and. It is also a strong antioxidant with many medical applications to date.

Is it safe? Are there side effects?

Isolated procyanidin B-2 to a purity exceeding 94% from apple juice and subjected it to a series of toxicological studies (Takahashi et al., 1999b). Results confirm the safety of topical application of procyanidin B-2 to human skin.

Effects on Hair loss

Acts as a protein kinase C (PKC) inhibitor, this molecules have been proved to stimulate (anagen phase) and to promote hair epithelial cell growth as (A.KAMIMURA AND T.TAKAHASHI) demonstrated back in 2001. The level of efficacy of 1 % procyanidin B-2 is concluded to compare favorably with minoxidil and finasteride therapy. In the procyanidin B-2 group, the increase in number of total hairs in the designated area (0.5 em square = 0.25 cml ) after the e-month trial was 6.68 ± 5.5 3 (mean ± SD)/0.25 cm2 , whereas in the placebo control group, the increase in number of total hair s was 0.0 8 ± 4.56 (mean ± SD)/0.25 cm2 (Table 2). It is calculated th at the increased number of total hairs in the designated area of procyanidin B-2 group subjects after the 6-month trial was significantly greater than that of the placebo control group subjects

Structure & Synthesis

20 kl of apple juice (Malus pumila Miller var) eluted and evaporated to produce 233 g of a dry solid.

Mechanisms of Action

The main mechanism of action of procyanidin B-2 is implied by its intensive growth-promoting action on hair epithelial cells (Takahashi et al., 1999a). The intensive anti-oxidative activity of procyanidin B-2 may be a significant contributor to its effects. The relation between male pattern baldness and inflammation has been pointed out by several researchers. It has been reported that lymphocytic inflammation was observed around hair follicles biopsied from patients showing male pattern baldness (Sueki et aI., 1999; Jaworsky et aI., 1992). Young et a1. (1991) also reported that the ratio of subjects showing inflammation of the scalp was 100 % in subjects with male pattern baldness, whereas the ratio was 66 % in non-balding subjects. Procyanidins are known to show the effect of decreasing inflammation due to their anti-oxidative properties (Haslam, 1996) and by their protease inhibiting action (Tixier et al., 1984). Therefore, it is supposed that the suppression of inflammation mediated by procyanidin B-2 returns the scalp to a healthy condition, consequently leading to a cure for baldness

1. Takahashi T, Kamiya T, Hasegawa A, Yokoo Y. Procyanidin oligomers selectively and intensively promote proliferation of mouse hair epithelial cells in vitro and activate hair follicle growth in vivo. J Invest Dermatol 1999; 112: 310±16
2. Takahashi T, Kamimura A, Shirai A, Yokoo Y. Several selective protein kinase C inhibitors including procyanidins promote hair growth. Skin Pharmacol Appl Skin Physiol 2000; 13: 133±42.
3. Haslam, E.: Natural polyphenols (vegetable tannins) as drugs: possible modes of action. ]. Nat. Prod. 59: 205-215, 1996
4. Takahashi, T., Yokoo, Y., Inoue, T., Ishii, A.: Toxicological studies on procyanidin B-2 for external application as a characterization and pharmacological approach. Chern. Pharm. Bull. (fokyo) 36: 828-833,198 8
5. Nishizuka Y. Studies and prospectives of the protein kinase C family for cellular regulation. Cancer 1989; 63: 1892±903.
6. Thompson R. S., Jacques D., Haslam E. and Tanner R. J. N. (1972) Plant proanthocyanidins. Part I. Introduction; the isolation, structure and distribution in nature of plant procyanidins. Journal of the Chemical Society. Perkin Transactions 1, Organic and Bio-organic Chemistry , 1387±1399.
7. Procyanidin B2. SAFETY DATA SHEET according to Regulation (EC) No. 1907/2006 as amended by (EC) No. 1272/2008. 19865.