Hair Growth Guide
Hair Growth Guide from Club Roots is the definitive resource for hair growth knowledge broken down from our research facility here in San Francisco, CA. There is tremendously exciting research happening in the areas of hair growth and delivery systems.
With that excitement, however, comes misinterpretation and hype. The guide cuts through the noise and distills the latest data, results, and conclusions from peer-reviewed, statistically significant studies.
Our goal is to produce a resource for you to understand the major pathways behind hair loss, the ingredients discovered and pathways they work on, and the new innovations in delivery systems that can help these ingredients work deep inside the dermal pappila, or the base of the hair follicle.
We did an exhaustive compilation of the pathways which can cause hair loss in partnership with our medical team. By building a treatment which uses a multilateral approach, our goal was to comprehensively address the different drivers of hair loss in a single formulation.
- Genetics and the changes in hair cycle
- Expression of insulin-like growth factor (IGF)-1 in the dermal papilla
- Senescent Alopecia
- Androgen Metabolism and the Androgen Receptor
- Hair Follicle Cycling and Signaling Molecules
- DHT Suppression
- Hair Follicle Microinflammation
- Perifollicular Fibrosis Management
- Anti-Oxidant Effects
- Prolonging and Managing Anagen Phase
- Role of Transforming Growth Factor Beta-1
- Oxidative Stress
- Increasing Vascular Endothelial Growth Factors (VEGF)
Ingredients in Spark
Let's look at the ingredients in Spark and see what pathways this product works on:
Retinol: This vitamin A derivative has been shown in medical studies to improve the results of hair growth when added with minoxidil . We have included it in Spark for this reason.
Adenosine: This ingredient has been shown in medical studies to thicken hair  when added topically, and has been included in Spark at the same concentration as this study.
Apple Extract: The Procyanadin B-2 from apples has been shown in multiple clinical studies to improve hair growth through suppression of protein kinase C . We have included it in Spark in a high concentration.
Lupine Seed Extract: This ingredient inhibits 5-alpha reductase II, stimulates cell metabolism, and increases VEGF synthesis, and has been proven in trials in France conducted by a biotech lab .
Aminexil: This ingredient is structurally very similar to minoxidil, and has been shown in trials to thicken hair through ion channel opening activity . We have included it in Spark.
Caffeine: This ingredient, even at very low concentrations, has been shown to improve hair growth in clinical studies using an anti-DHT effect . We have included it in Spark in a much higher concentration than this study.
Advanced Features of Spark
A note on the research cited:
In addition to these medical papers cited, we have conducted our own clinical trials on volunteers and many members of the Roots Hair Club team. We hope you try Roots Spark and experience the next generation of what is available for your hair.
 The Additive Effects of Minoxidil and Retinol on Human Hair Growth in Vitro
 Adenosine increases anagen hair growth and thick hairs in Japanese women with female pattern hair loss
 Procyanidin B-2, extracted from apples, promotes hair growth: a laboratory study
 Growth Phase of Hair Stimulation: An Anti-Hair Loss Strategy
 Medical Treatments for male and female pattern hair loss
 Effect of caffeine and testosterone on the proliferation of human hair follicles in vitro