Ekspression af insulinlignende vækstfaktorer

Af alle de cytokiner eller vækstfaktorer, der er blevet postuleret at spille en rolle i hårsækken, er insulinlignende vækstfaktor-1 (IGF-1) kendt for at blive reguleret af androgener. Dermale Papila-celler fra skaldede hovedbundsfollikler viste sig at udskille signifikant mindre IGF-1, IGFBP-2 og IGFBP-4 (P < 0,05) end deres ikke-skallede modstykker. Vores data bekræftede, at nedreguleringen af ​​IGF-1 kan være en af ​​de vigtige mekanismer, der bidrager til mandlig skaldethed. Produceret af mesenkymale dermale papilaceller, hæmmer apoptose og fremmer epitelcellevækst.

Ekspressionen af ​​insulinlignende vækstfaktor (IGF)-1 i den dermale papilla diskuteres for at spille en vigtig rolle i udviklingen af ​​mønsterskaldethed. Ældre mænd med vertex skaldet viste højere plasmaniveauer af IGF-1 og lavere cirkulerende niveauer af IGF-bindende protein 3. Der blev fundet en nedsat ekspression af IGF-1 i det skaldede hovedbundsvæv. Genlocuset for IGF-1 kan findes på kromosom 12 (12q22-q23)

Teoretisk set kan behandlinger, der kan stimulere udskillelsen af ​​IGF-1, bremse hårtab. IGF-1 har også vist sig at være opreguleret i DP-celler fra patienter med AGA, som reagerer på finasterid.

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Roots Shampoo & Conditioner Set